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The Use of Adenoviral Vectors for Genetic Manipulation and Analysis of Primitive Hematopoietic Cells

[ Vol. 1 , Issue. 3 ]


Craig T. Jordan, Elio F. Vanin and Frank C. Marini   Pages 257 - 266 ( 10 )


Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.


Adenoviral Vectors, Primitive Hematopoietic Cells, Hematopoietic Gene, Fiber Protein, antibody redirection, Hybrid Vectors, Capsid Proteins


Markey Cancer Center, 800 Rose St. Room CC407, Lexington, KY, 40536-0093, USA

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