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The Use of Adenoviral Vectors for Genetic Manipulation and Analysis of Primitive Hematopoietic Cells

[ Vol. 1 , Issue. 3 ]

Author(s):

Craig T. Jordan, Elio F. Vanin and Frank C. Marini   Pages 257 - 266 ( 10 )

Abstract:


Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.

Keywords:

Adenoviral Vectors, Primitive Hematopoietic Cells, Hematopoietic Gene, Fiber Protein, antibody redirection, Hybrid Vectors, Capsid Proteins

Affiliation:

Markey Cancer Center, 800 Rose St. Room CC407, Lexington, KY, 40536-0093, USA



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