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Gene Modified Cell Transplantation for Vascular Regeneration

[ Vol. 7 , Issue. 1 ]


Satoshi Murasawa and Takayuki Asahara   Pages 1 - 6 ( 6 )


Cell Transplantation is one of the powerful tools to ameliorate the capillary flow in ischemic condition. EPC (Endothelial Progenitor Cell) was identified in adult peripheral blood and thought to be a suitable candidate for cell transplantation. Also, gene therapy is already promising choice for enhancing angiogenic property. The combination of cell transplantation and gene therapy should be more effective way to regenerate vasculature in ischemic region. Recently, several research reports have come out regarding gene modified cell transplantation. We will mainly focus on the background of EPC, and then gene modified EPC findings in this review.


Endothelial Progenitor Cell (EPC), Gene modified cell therapy, VEGF, TERT, Vasculogenesis


Group of Vascular Regeneration, Institute of Biomedical Research and Innovation/Stem Cell TranslationalResearch Laboratory, RIKEN Kobe Institute Center for Developmental Biology, Kobe, Japan.

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