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Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

[ Vol. 21 , Issue. 3 ]

Author(s):

Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami and Rajib Bandopadhyay*   Pages 207 - 215 ( 9 )

Abstract:


Cancer therapy describes the treatment of cancer, often with surgery, chemotherapy, and radiotherapy. Additionally, RNA interference (RNAi) is likely to be considered a new emerging, alternative therapeutic approach for silencing/targeting cancer-related genes. RNAi can exert antiproliferative and proapoptotic effects by targeting functional carcinogenic molecules or knocking down gene products of cancer-related genes. However, in contrast to conventional cancer therapies, RNAi based therapy seems to have fewer side effects. Transcription signal sequence and conserved sequence analysis-showed that microorganisms could be a potent source of non-coding RNAs. This review concluded that mapping of RNAi mechanism and RNAi based drug delivery approaches is expected to lead a better prospective of cancer therapy.

Keywords:

Cancer therapy, RNA interference, carcinogenic, microorganisms, drugs delivery, RNAi based therapy.

Affiliation:

UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal, Haldia Institute of Technology, HIT College Rd, Kshudiram Nagar, Haldia-721657, West Bengal, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal

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