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Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches

[ Vol. 15 , Issue. 2 ]

Author(s):

Xiaoyu Wang, Zongguang Tai, Wei Zhang and Shen Gao   Pages 120 - 141 ( 22 )

Abstract:


Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality rates, especially in East Asia. Gene therapy is a potential approach for treating HCC. An efficient and safe gene delivery method is a crucial factor for HCC gene therapy. In recent years, gene delivery systems, including viral and non-viral gene vectors, bacteria, and physical methods, have undergone substantial development. Among them, various non-viral vectors have been studied widely and in detail because they are relatively safe and have a high capacity. In this review, we focus on current and emerging HCC delivery techniques and address the challenges involved in the use and improvement of non-viral vectors.

Keywords:

Gene therapy, hepatocellular carcinoma, non-viral vector, physical methods, viral vectors.

Affiliation:

Department of Pharmaceutics, Changhai Hospital, 168# Changhai Road, Shanghai 200433, China.



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