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Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

[ Vol. 9 , Issue. 5 ]

Author(s):

Juan F. Vera, Malcolm K. Brenner and Gianpietro Dotti   Pages 396 - 408 ( 13 )

Abstract:


Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

, Immunotherapy, of, Human, Cancers, Using, Gene, Modified, T, Lymphocytes

Affiliation:

Center for Cell and Gene Therapy, Baylor College of Medicine, 6621 Fannin Street, MC 3-3320, Houston, Texas 77030, USA.



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