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Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review

Author(s):

Desyrre V Tedeschi, Anderson F da Cunha, Márcia R Cominetti and Renata Valle Pedroso*   Pages 1 - 12 ( 12 )

Abstract:


Background: Alzheimer's disease (AD) is the main cause of dementia and it is a progressive neurogenerative disease characterized by the accumulation of neurofibrillary tangles and senile plaques. There is currently no cure, however some treatments are available to slow down the progression of the disease, including gene therapy, which has been investigated as having great potential for the treatment of AD.

Objective: Thus, the aim of this review was to identify the efficacy of gene therapy to restore cognition in Alzheimer’s disease.

Methods: a systematic review was carried out using papers published up to May 2020 and available in the Web of Science, Scopus, and Medline/PUBMED databases. Articles were considered for inclusion if they were original research that investigated the effects of gene therapy on cognition in AD. The methodological quality of the selected studies was evaluated using the Risk of Bias Tool for Animal Intervention Studies (SYRCLE’s Rob tool), and the Jadad Scale.

Results: Most preclinical studies obtained positive results in improving memory and learning in mice that underwent treatment with gene therapy. On the other hand, clinical studies have obtained inconclusive results related to the delivery methods of the viral vector used in gene therapy.

Conclusion: Gene therapy showed a great potential for the treatment of AD in preclinical trials, but results should be interpreted with caution since preclinical studies presented limitations to predict the efficacy of the treatment outcome in humans.

Keywords:

dementia, therapy, cognition, ageing, Alzheimer’s disease, genetics.

Affiliation:

Federal University of São Carlos, Rodovia Washington Luís Km 310 – 13565-905, São Carlos SP, Department of Genetics and Evolution, Federal University of Sao Carlos, Rodovia Washington Luís Km 310 – 13565- 905, São Carlos SP, Department of Gerontology, Federal University of São Carlos, Rodovia Washington Luís Km 310 – 13565-905, São Carlos SP, Department of Gerontology, Federal University of São Carlos, Rodovia Washington Luís Km 310 – 13565-905, São Carlos SP



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