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Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

Author(s):

Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami and Rajib Bandopadhyay*   Pages 1 - 9 ( 9 )

Abstract:


Cancer therapy describes treatment of cancer, often with surgery, chemotherapy, and radiotherapy. Additionally, RNA interference (RNAi) is likely to consider as a new emerging, alternative therapeutic approach for silencing/targeting cancer-related genes. RNAi can exert antiproliferative and proapoptotic effects by targeting functional carcinogenic molecules or knocking down gene products of cancer-related genes. However, in contrast to conventional cancer therapies, RNAi based therapy is seemed to have fewer side effects. Transcription signal sequence and conserved sequence analysis showed that microorganisms could be a potent source of non-coding RNAs. This review concluded thatmapping of RNAi mechanism and RNAi based drugs delivery approaches are expected to lead the better prospective of cancer therapy.

Keywords:

Cancer therapy, RNA interference, carcinogenic, microorganisms, drugs delivery

Affiliation:

UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal,, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal,, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal,, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal,, Haldia Institute of Technology, HIT College Rd, Kshudiram Nagar, Haldia-721657, West Bengal, UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal



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