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High Mobility Group Box 1: An Immune-regulatory Protein

[ Vol. 19 , Issue. 2 ]

Author(s):

Jingjing Zhao, Tianle Sun, Shengdi Wu* and Yufeng Liu*   Pages 100 - 109 ( 10 )

Abstract:


High mobility group box 1 (HMGB1) presents in almost all somatic cells as a component of the cell nucleus. It is necessary for transcription regulation during cell development. Recent studies indicate that extracellular HMGB1, coming from necrotic cells or activated immune cells, triggers inflammatory response whereas intracellular HMGB1 controls the balance between autophagy and apoptosis. In addition, reduced HMGB1 can effectively mediate tissue regeneration. HMGB1, therefore, is regarded as a therapeutic target for inflammatory diseases. In this review, we summarized and discussed the immunomodulatory effect of HMGB1.

Keywords:

HMGB1, inflammatory response, autophagy, apoptosis, tissue regeneration, NLSs.

Affiliation:

Department of Intensive Care Medicine, Hefei No. 2 People Hospital, Hefei 230000, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215000, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, Department of Nursing, General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032

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