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CRISPR/Cas9 Editing to Facilitate and Expand Drug Discovery

[ Vol. 17 , Issue. 4 ]

Author(s):

Francis Robert, Sidong Huang and Jerry Pelletier*   Pages 275 - 285 ( 11 )

Abstract:


Introduction: The ability of most laboratories to easily access CRISPR/Cas9 engineering tools has caused a revolution in biology. One of the areas that will continue to be impacted by genome editing is the drug discovery process.

Objective: CRISPR/Cas9 will not only serve to accelerate the drug discovery pipeline, but also streamline line it by identifying high-value targets, facilitating the validation of drug: target interactions and mechanisms of action, and stimulating the development of phenotype-based high throughput screens as alternatives to target-based assays.

Conclusion: We review the literature and hurdles that have been overcome to develop the current generation of tools being used to enrich the drug discovery paradigm.

Keywords:

CRISPR/Cas9, Drug discovery, Target: drug interaction validation, Base editing, Druggable genome, RNA.

Affiliation:

Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6



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